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Article

Perturbations of the AKT signaling pathway in human cancer.

Oncogene - 14 Nov 2005

Altomare Deborah A, Testa Joseph R

Abstract excerpt

AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse cellular processes including cell proliferation and survival, cell size and response to nutrient availability, tissue invasion and angiogenesis. Many oncoproteins and tumor suppressors implicated in cell signaling/metabolic regulation converge...

Read the complete abstract on PubMed

Topics

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Share to Cell Survival
Share to Cell Transformation, Neoplastic
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Invasiveness

Share to Neovascularization, Pathologic

Share to Protein Kinases

Share to Proto-Oncogene Proteins c-akt

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 16288292
DOI: 10.1038/sj.onc.1209085

Genes

PTEN
TSC1
TSC2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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