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Article

Nuclear PI3K signaling in cell growth and tumorigenesis

13 Apr 2015

Abstract excerpt

The PI3K/Akt signaling pathway is a major driving force in a variety of cellular functions. Dysregulation of this pathway has been implicated in many human diseases including cancer. While the activity of the cytoplasmic PI3K/Akt pathway has been extensively studied, the functions of these molecules and their effector proteins within the nucleus are poorly understood. Harboring key cellular processes such as DNA...

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PMID: 25918701
DOI: 10.3389/fcell.2015.00024

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