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Article

Mcl-1 Interacts with Akt to Promote Lung Cancer Progression

29 Oct 2019

Abstract excerpt

Abstract Mcl-1 is a unique antiapoptotic Bcl2 family protein that functions as a gatekeeper in manipulating apoptosis and survival in cancer cells. Akt is an oncogenic kinase that regulates multiple cellular functions and its activity is significantly elevated in human cancers. Here we discovered a cross-talk between Mcl-1 and Akt in promoting lung cancer cell growth. Depletion of endogenous Mcl-1 from human lung...

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Share to Cancer Mechanisms and Therapy
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Identifiers

PMID: 31662324
DOI: 10.1158/0008-5472.can-19-0950

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