Article
Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates
2018-05-29
Abstract excerpt
The immortal strand hypothesis poses that stem cells could produce differentiated progeny while conserving the original template strand, thus avoiding accumulating somatic mutations. However, quantitating the extent of non-random DNA strand segregation in human stem cells remains difficult in vivo . Here we show that the change of the mean and variance of the mutational burden with age in healthy human tissues al...
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Identifiers and source
- Literature Corpus work
- 9e37d410-940d-55f6-bb07-c0a438466c96
- DOI
- 10.1101/332734