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Article

Intestinal stem cells protect their genome by selective segregation of template DNA strands.

Journal of cell science - 1 Jun 2002

Potten Christopher S, Owen Gary, Booth Dawn

Abstract excerpt

The stem cells in the crypts of the small intestinal mucosa divide about a thousand times during the lifespan of a laboratory mouse, and yet they show little evidence of any decline in proliferative potential and rarely develop carcinogenic mutations, suggesting that their genome is extremely well protected. Protection against DNA-replication-induced errors can be achieved by the selective sorting of old...

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Identifiers

PMID: 12006622
DOI: 10.1242/jcs.115.11.2381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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