Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The (not so) immortal strand hypothesis

24 Jan 2015

Abstract excerpt

BACKGROUND: Non-random segregation of DNA strands during stem cell replication has been proposed as a mechanism to minimize accumulated genetic errors in stem cells of rapidly dividing tissues. According to this hypothesis, an "immortal" DNA strand is passed to the stem cell daughter and not the more differentiated cell, keeping the stem cell lineage replication error-free. After it was introduced, experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25700960
DOI: 10.1016/j.scr.2015.01.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The (not so) immortal strand hypothesisPMID 25700960Read ↗

Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation ratesSemantic proximity Read ↗

Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates.Semantic proximity Read ↗

The immortal strand hypothesis: segregation and reconstruction.Semantic proximity Read ↗

[Immortal DNA or epigenetic signature ?].Semantic proximity Read ↗

Somatic stem cells and the kinetics of mutagenesis and carcinogenesisSemantic proximity Read ↗

Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer Initiation.Semantic proximity Read ↗

Stem cell replication, somatic mutations and role of randomness in the development of cancerSemantic proximity Read ↗

A new mechanism for aging: chemical "age spots" in immortal DNA strands in distributed stem cells.Semantic proximity Read ↗

Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregationSemantic proximity Read ↗

Intestinal stem cells protect their genome by selective segregation of template DNA strands.Semantic proximity Read ↗

Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.Semantic proximity Read ↗

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.