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Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation

29 Mar 2011

Abstract excerpt

The idea that stem cells of adult tissues with high turnover are protected from DNA replication-induced mutations by maintaining the same 'immortal' template DNA strands together through successive divisions has been tested in several tissues. In the epithelium of the small intestine, the provided evidence was based on the assumption that stem cells are located above Paneth cells. The results of genetic...

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PMID: 21448157
DOI: 10.1038/ncomms1260

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