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Article

The immortal strand hypothesis: segregation and reconstruction.

Cell - 29 Jun 2007

Rando Thomas A

Abstract excerpt

The immortal strand hypothesis posits that the propensity of stem cell compartments to give rise to cancer in later life can be minimized if stem cells, during the process of self-renewal, retain those DNA strands with the fewest mutations acquired during DNA replication. In this Essay, I explore evidence in support of the hypothesis, the biological implications, and the key questions that remain to be answered...

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Share to Cellular Senescence
Share to Chromosome Segregation
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cell Transformation, Neoplastic

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Source

Identifiers

PMID: 17604710
DOI: 10.1016/j.cell.2007.06.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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