Article

Functional diversity of the <i>TP53</i> mutome revealed by saturating CRISPR mutagenesis

2023-03-10

Abstract excerpt

The tumor suppressor gene TP53 is the most frequently mutated gene in various cancers. Unlike other tumor suppressors, TP53 is mostly hit by missense mutations, of which more than 2,000 have been described in cancer patients. To take advantage of TP53 mutation status for personalized therapy, a deeper knowledge of the functional ramifications of specific mutations is required as evidence of the functional heter...

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Literature Corpus work: 9e21d405-9d70-54bd-83cd-121447c8ed1b
DOI: 10.1101/2023.03.10.531074

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