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Article

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.

Nature reviews. Clinical oncology - 1 Jan 2018

Sabapathy Kanaga, Lane David P

Abstract excerpt

TP53, which encodes the tumour-suppressor protein p53, is the most frequently mutated gene across all cancer types. The presence of mutant p53 predisposes to cancer development, promotes the survival of cancer cells, and is associated with ineffective therapeutic responses and unfavourable prognoses. Despite these effects, no drug that abrogates the oncogenic functions of mutant p53 has yet been approved for the...

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PMID: 28948977
DOI: 10.1038/nrclinonc.2017.151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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