High throughput evaluation of genetic variants with prime editing sensor libraries

Abstract excerpt

Many human diseases have a strong association with diverse types of genetic alterations. These diseases include cancer, in which tumor genomes often harbor a complex spectrum of single-nucleotide alterations and chromosomal rearrangements that can perturb gene function in ways that remain poorly understood. Some cancer-associated genes exhibit a tremendous degree of mutational heterogeneity, which may impact disea...

Topics

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• CRISPR-Cas Systems
• Gene Editing
• Genetic Variation
• High-Throughput Screening Assays
• Neoplasms
• Phenotype
• RNA, Guide, CRISPR-Cas Systems
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

9c1d3822-7d6e-595e-8f09-bef15dde90bb

DOI

10.1101/2022.10.26.513842