Article
Mutant p53: it's not all one and the same.
Cell death and differentiation - 1 May 2022
Kennedy Margaret C, Lowe Scott W
Abstract excerpt
Mutation of the TP53 tumor suppressor gene is the most common genetic alteration in cancer, and almost 1000 alleles have been identified in human tumors. While virtually all TP53 mutations are thought to compromise wild type p53 activity, the prevalence and recurrence of missense TP53 alleles has motivated countless research studies aimed at understanding the function of the resulting mutant p53 protein. The data...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.