Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells.

doi:10.1158/2159-8290.CD-23-0402

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Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells.

Cancer discovery - 8 Feb 2024

Wang Zilu, Burigotto Matteo, Ghetti Sabrina, Vaillant François, Tan Tao, Capaldo Bianca D, Palmieri Michelle, Hirokawa Yumiko, Tai Lin, Simpson Daniel S, Chang Catherine, Huang Allan Shuai, Lieschke Elizabeth, Diepstraten Sarah T, Kaloni Deeksha, Riffkin Chris, Huang David C S, Li Wai Suen Connie S N, Garnham Alexandra L, Gibbs Peter, Visvader Jane E, Sieber Oliver M, Herold Marco J, Fava Luca L, Kelly Gemma L, Strasser Andreas

Abstract excerpt

Mutations in the tumor suppressor TP53 cause cancer and impart poor chemotherapeutic responses, reportedly through loss-of-function, dominant-negative effects and gain-of-function (GOF) activities. The relative contributions of these attributes is unknown. We found that removal of 12 different TP53 mutants with reported GOFs by CRISPR/Cas9 did not impact proliferation and response to chemotherapeutics of 15 human...

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PMID: 37877779
DOI: 10.1158/2159-8290.CD-23-0402
PMCID: PMC10850947

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TP53

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