Article
Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries.
Scientific reports - 23 Nov 2020
Carbonnier Vincent, Leroy Bernard, Rosenberg Shai, Soussi Thierry
Abstract excerpt
The diagnosis of somatic and germline TP53 mutations in human tumors or in individuals prone to various types of cancer has now reached the clinic. To increase the accuracy of the prediction of TP53 variant pathogenicity, we gathered functional data from three independent large-scale saturation mutagenesis screening studies with experimental data for more than 10,000 TP53 variants performed in different settings...
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