Article

Loss of mutant TP53 does not impair the sustained proliferation, survival or metastasis of diverse cancer cells

2020-03-31

Abstract excerpt

The tumour suppressor TP53 is the most frequently mutated gene in human cancer and these aberrations confer poor chemotherapeutic responses 1-3 . Point mutations typically cluster in the DNA binding domain, with certain ‘hot-spot’ residues disproportionally represented 1-4 These mutations abrogate binding of the TP53 transcription factor to DNA and thereby prevent upregulation of genes critical for tumour suppr...

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Literature Corpus work: d945ae0e-49a0-52c3-9aca-649075b44c9b
DOI: 10.1101/2020.03.30.015263

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