Article

Mutational Landscape of TP53 Across Cancer Types

2025-08-15

Abstract excerpt

The TP53 gene is the most frequently mutated tumor suppressor in human cancers, but its mutation patterns vary across tumor types. Using data from cBioPortal (downloaded 9 August 2025), we analyzed 4,245 TP53 mutation events in 10,967 unique tumor samples from 32 cancer studies, covering 27 cancer types. Mutations were classified into missense, nonsense, frameshift, in-frame indels, splice-site variants, and fu...

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Literature Corpus work: 2914b110-b9ab-559c-b333-fe152d3aba9d
DOI: 10.1101/2025.08.12.669884

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