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Article

Targeting mutant p53 in cancer: a long road to precision therapy

3 Nov 2016

Abstract excerpt

The TP53 tumor suppressor is the most frequently mutated gene in human cancers. In recent years, a blooming of research efforts based on both cell lines and mouse models have highlighted how deeply mutant p53 proteins affect fundamental cellular pathways with cancer-promoting outcomes. Neomorphic mutant p53 activities spread over multiple levels, impinging on chromatin structure, transcriptional regulation and...

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PMID: 27808469
DOI: 10.1111/febs.13948

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