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Loss of a conserved C-terminal region of the <i>Aspergillus fumigatus</i> AtrR transcriptional regulator leads to a gene-specific defect in target gene expression

2024-05-23

Abstract excerpt

Treatment of fungal infections associated with the filamentous fungus Aspergillus fumigatus is becoming more problematic as this organism is developing resistance to the main chemotherapeutic drug at an increasing rate. Azole drugs represent the current standard-of-care in treatment of aspergillosis with this drug class acting by inhibiting a key step in biosynthesis of the fungal sterol ergosterol. Azole compoun...

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Literature Corpus work
9e0dc740-51db-5252-8150-a32c895f9cde
DOI
10.1101/2024.05.22.595332
Open publication

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Loss of a conserved C-terminal region of the <i>Aspergillus fumigatus</i> AtrR transcriptional regulator leads to a gene-specific defect in target gene expressionDOI 10.1101/2024.05.22.595332
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