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Complex and critical roles for the AtrR transcription factor in control of <i>cyp51A</i> expression in <i>Aspergillus fumigatus</i>

2022-01-29

Abstract excerpt

Aspergillus fumigatus is the major filamentous fungal pathogen in humans. The gold standard treatment of A. fumigatus is based on azole drug use but the appearance of azole-resistant isolates is increasing at an alarming rate. The cyp51A gene encodes the enzymatic target of azole drugs and azole-resistant alleles of cyp51A often have an unusual genetic structure containing a duplication of a 34 or 46 bp region...

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Literature Corpus work
fc926cf8-ace5-543d-a4a8-98636c43a51b
DOI
10.1101/2022.01.28.478276
Open publication

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Complex and critical roles for the AtrR transcription factor in control of <i>cyp51A</i> expression in <i>Aspergillus fumigatus</i>DOI 10.1101/2022.01.28.478276
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