Back to search

Article

<i>Aspergillus fumigatus ffmA</i> encodes a C <sub>2</sub> H <sub>2</sub> -containing transcriptional regulator that modulates azole resistance and is required for normal growth

2021-11-18

Abstract excerpt

The production of a collection of disruption mutant strains corresponding to a large number of transcription factors from the filamentous fungal pathogen Aspergillus fumigatus has permitted rapid identification of transcriptional regulators involved in a range of different processes. Here we characterize a gene designated ffmA (favors fermentative metabolism) as an C 2 H 2 -containing transcription factor that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
29309980-1cc6-5b08-bb8a-858adfe8d5b9
DOI
10.1101/2021.11.17.469059
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>Aspergillus fumigatus ffmA</i> encodes a C <sub>2</sub> H <sub>2</sub> -containing transcriptional regulator that modulates azole resistance and is required for normal growthDOI 10.1101/2021.11.17.469059
Transcription factor FfmA interacts both physically and genetically with AtrR to properly regulate gene expression in the fungus <i>Aspergillus fumigatus</i>Semantic proximity
Loss of a conserved C-terminal region of the <i>Aspergillus fumigatus</i> AtrR transcriptional regulator leads to a gene-specific defect in target gene expressionSemantic proximity
Complex and critical roles for the AtrR transcription factor in control of <i>cyp51A</i> expression in <i>Aspergillus fumigatus</i>Semantic proximity
Biochemical identification of a nuclear coactivator protein required for AtrR-dependent gene regulation in <i>Aspergillus fumigatus</i>Semantic proximity
AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus.Semantic proximity
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatusSemantic proximity
The C 2 H 2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatusSemantic proximity
Olorofim and the azoles are antagonistic in A. fumigatus and functional genomic screens reveal mechanisms of cross resistance.Semantic proximity
Elevated mutation rates in the multi-azole resistant <i>Aspergillus fumigatus</i> clade drives rapid evolution of antifungal resistanceSemantic proximity
Genome-Wide Association for Itraconazole Sensitivity in Non-Resistant Clinical Isolates of <i>Aspergillus fumigatus</i>Semantic proximity
A long non-coding RNA, <i>afu-254</i> , is required for the oxidative stress response, cell wall stress response, azole susceptibility and virulence in <i>Aspergillus fumigatus</i>Semantic proximity
Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant.Semantic proximity
Select a neighboring publication to make it the new centre.