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Article

Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene.

Scientific reports - 9 Dec 2016

Hagiwara Daisuke, Watanabe Akira, Kamei Katsuhiko

Abstract excerpt

Azoles are widely used for controlling fungal growth in both agricultural and medical settings. The target protein of azoles is CYP51, a lanosterol 14-α-demethylase involved in the biosynthesis of ergosterol. Recently, a novel azole resistance mechanism has arisen in pathogenic fungal species Aspergillus fumigatus. Resistant strains contain a 34-bp or 46-bp tandem repeat (TR) in the promoter of cyp51A, and have...

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Share to Antifungal Agents
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Azoles

Share to Cytochrome P-450 Enzyme System

Share to Drug Resistance, Multiple, Fungal

Share to Fungicides, Industrial

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Source

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Identifiers

PMID: 27934927
DOI: 10.1038/srep38833
PMCID: PMC5146965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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