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Article

A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions.

PLoS pathogens - 1 Jan 2017

Hagiwara Daisuke, Miura Daisuke, Shimizu Kiminori, Paul Sanjoy, Ohba Ayumi, Gonoi Tohru, Watanabe Akira, Kamei Katsuhiko, Shintani Takahiro, Moye-Rowley W Scott, Kawamoto Susumu, Gomi Katsuya

Abstract excerpt

Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To elucidate mechanisms underlying azole resistance, we identified a novel transcription factor that is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28052140
DOI: 10.1371/journal.ppat.1006096
PMCID: PMC5215518

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A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions.PMID 28052140Read ↗

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