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The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus

22 Jan 2020

Abstract excerpt

The frequency of antifungal resistance, particularly to the azole class of ergosterol biosynthetic inhibitors, is a growing global health problem. Survival rates for those infected with resistant isolates are exceptionally low. Beyond modification of the drug target, our understanding of the molecular basis of azole resistance in the fungal pathogen Aspergillus fumigatus is limited. We reasoned that clinically...

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PMID: 31969561
DOI: 10.1038/s41467-019-14191-1

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