Back to search

Article

Transcription factor FfmA interacts both physically and genetically with AtrR to properly regulate gene expression in the fungus <i>Aspergillus fumigatus</i>

2023-06-07

Abstract excerpt

Transcriptional regulation of azole resistance in the filamentous fungus Aspergillus fumigatus is a key step in development of this problematic clinical phenotype. We and others have previously described a C2H2-containing transcription factor called FfmA that is required for normal levels of voriconazole susceptibility and expression of an ATP-binding cassette transporter gene called abcG1 . Null alleles of ffm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
98c523a4-a776-56b3-a4bb-91ca9b9a6b6c
DOI
10.1101/2023.06.06.543935
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Transcription factor FfmA interacts both physically and genetically with AtrR to properly regulate gene expression in the fungus <i>Aspergillus fumigatus</i>DOI 10.1101/2023.06.06.543935
<i>Aspergillus fumigatus ffmA</i> encodes a C <sub>2</sub> H <sub>2</sub> -containing transcriptional regulator that modulates azole resistance and is required for normal growthSemantic proximity
Loss of a conserved C-terminal region of the <i>Aspergillus fumigatus</i> AtrR transcriptional regulator leads to a gene-specific defect in target gene expressionSemantic proximity
Biochemical identification of a nuclear coactivator protein required for AtrR-dependent gene regulation in <i>Aspergillus fumigatus</i>Semantic proximity
AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus.Semantic proximity
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatusSemantic proximity
Complex and critical roles for the AtrR transcription factor in control of <i>cyp51A</i> expression in <i>Aspergillus fumigatus</i>Semantic proximity
A long non-coding RNA regulates in vitro and in vivo triazole antifungal susceptibility in <i>Aspergillus fumigatus</i>Semantic proximity
Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant cyp51A Promoters in Aspergillus fumigatusSemantic proximity
Olorofim and the azoles are antagonistic in A. fumigatus and functional genomic screens reveal mechanisms of cross resistance.Semantic proximity
Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant.Semantic proximity
The C 2 H 2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatusSemantic proximity
The Transcriptome Response to Azole Compounds in Aspergillus fumigatus Shows Differential Gene Expression across Pathways Essential for Azole Resistance and Cell SurvivalSemantic proximity
Select a neighboring publication to make it the new centre.