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Set1-mediated histone H3K4 methylation is required for azole induction of the ergosterol biosynthesis genes and antifungal drug resistance in <i>Candida glabrata</i>

2021-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Candida glabrata is an opportunistic pathogen that has developed the ability to adapt and thrive under azole treated conditions. The common mechanisms that can result in Candida drug resistance are due to mutations or overexpression of the drug efflux pump or the target of azole drugs, Cdr1 and Erg11, respectively. However, the role of epigenetic histone modifications in azole-induced gene expr...

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Literature Corpus work
9c0a1796-ed91-5181-acd0-440bcb268bf3
DOI
10.1101/2021.11.17.469015
Open publication

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