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Article

Cancer of Unknown Primary (CUP): genetic evidence for a novel nosological entity? A case report.

EMBO molecular medicine - 7 Jul 2020

Benvenuti Silvia, Milan Melissa, Geuna Elena, Pisacane Alberto, Senetta Rebecca, Gambardella Gennaro, Stella Giulia M, Montemurro Filippo, Sapino Anna, Boccaccio Carla, Comoglio Paolo M

Abstract excerpt

Cancer of unknown primary (CUP) is an obscure disease characterized by multiple metastases in the absence of a primary tumor. No consensus has been reached whether CUPs are simply generated from cancers that cannot be detected or whether they are the manifestation of a still unknown nosological entity. Here, we report the complete expression and genetic analysis of multiple synchronous metastases harvested at...

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Identifiers

PMID: 32511869
DOI: 10.15252/emmm.201911756
PMCID: PMC7338804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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