Article

Tumor-Origin.com: A Machine Learning Platform for Predicting Tumor Tissue of Origin from Somatic Mutation Profiles

2026-01-01

Abstract excerpt

<h4>ABSTRACT</h4> Standard pathology workup sometimes fails to definitively identify tumor tissue-of-origin in cancers with ambiguous diagnoses or unknown primary sites, complicating treatment decisions. Molecular assays can aid diagnosis but require additional tissue and increase healthcare costs. Intending to leverage routinely collected somatic mutation profiles from comprehensive genomic profiling, we develop...

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Literature Corpus work: 1fcf7979-e500-5ff2-b1bc-a21ee1bd6ec1
DOI: 10.64898/2025.12.27.25343092

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