Article
Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: the role of massively parallel sequencing.
Molecular oncology - 1 Feb 2014
De Mattos-Arruda Leticia, Bidard Francois-Clement, Won Helen H, Cortes Javier, Ng Charlotte K Y, Peg Vicente, Nuciforo Paolo, Jungbluth Achim A, Weigelt Britta, Berger Michael F, Seoane Joan, Reis-Filho Jorge S
Abstract excerpt
In this proof-of-principle study, we sought to define whether targeted capture massively parallel sequencing can be employed to determine the origin of metastatic deposits in cases of synchronous primary malignancies and metastases in distinct anatomical sites. DNA samples extracted from synchronous tumor masses in the breast, adnexal, and pelvic-peritoneal regions from a 62-year-old BRCA1 germline mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.