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Article

Four Metachronous Cancers: Mutation Profiling Can Be Used to Distinguish Multiple Primary Cancers from Metastases.

Internal medicine (Tokyo, Japan) - 1 Jan 2026

Hisanaga Etsuko, Sano Takaaki, Yokoo Hideaki

Abstract excerpt

Distinguishing between primary and metastatic tumors is critical in patients with multiple cancers. We present the case of a man in his 70s with quadruple carcinoma, squamous cell carcinoma in both lungs, invasive urothelial carcinoma of the bladder, and esophageal cancer, discovered during follow-up after sigmoid colon cancer surgery. A histopathological analysis, including immunostaining, could not confirm...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40603091
DOI: 10.2169/internalmedicine.5301-25
PMCID: PMC12854961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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