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Article

Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era.

PloS one - 1 Jan 2015

Kim Richard, Schell Michael J, Teer Jamie K, Greenawalt Danielle M, Yang Mingli, Yeatman Timothy J

Abstract excerpt

INTRODUCTION: Metastasis is thought to be a clonal event whereby a single cell initiates the development of a new tumor at a distant site. However the degree to which primary and metastatic tumors differ on a molecular level remains unclear. To further evaluate these concepts, we used next generation sequencing (NGS) to assess the molecular composition of paired primary and metastatic colorectal cancer tissue...

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Identifiers

PMID: 25974029
DOI: 10.1371/journal.pone.0126670
PMCID: PMC4431733

Genes

APC
KRAS
ADAMTS20
MACF1
RASA1
SMAD2
SMAD3
SMAD4
TTN
WNT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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