Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases.

doi:10.1038/s41588-024-02019-8

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Article

Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases.

Nature genetics - 1 Dec 2024

Tian Chi, Zhang Yuntian, Tong Yihan, Kock Kian Hong, Sim Donald Yuhui, Liu Fei, Dong Jiaqi, Jing Zhixuan, Wang Wenjing, Gao Junbin, Tan Le Min, Han Kyung Yeon, Tomofuji Yoshihiko, Nakano Masahiro, Buyamin Eliora Violain, Sonthalia Radhika, Ando Yoshinari, Hatano Hiroaki, Sonehara Kyuto, Jin Xin, Loh Marie, Chambers John, Hon Chung-Chau, Choi Murim, Park Jong-Eun, Ishigaki Kazuyoshi, Okamura Tomohisa, Fujio Keishi, Okada Yukinori, Park Woong-Yang, Shin Jay W, Roca Xavier, Prabhakar Shyam, Liu Boxiang

Abstract excerpt

Alternative splicing contributes to complex traits, but whether this differs in trait-relevant cell types across diverse genetic ancestries is unclear. Here we describe cell-type-specific, sex-biased and ancestry-biased alternative splicing in ~1 M peripheral blood mononuclear cells from 474 healthy donors from the Asian Immune Diversity Atlas. We identify widespread sex-biased and ancestry-biased differential...

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Identifiers

PMID: 39627432
DOI: 10.1038/s41588-024-02019-8
PMCID: PMC11631754

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