Article

Infection and herbicide exposure implicate c-Abl kinase in α-Synuclein Ser129 phosphorylation

2025-01-30

Abstract excerpt

<h4>Background</h4> Parkinson’s disease is a complex multifactorial neurodegenerative disorder characterized by α-Synuclein aggregation in Lewy bodies, with phosphorylation at serine 129 (pSer129) being a critical pathological hallmark. However, the exact mechanisms by which environmental triggers lead to this disease phenotype remain poorly understood. In this study we compare the effects of an exemplary infecti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9dfbaf16-4744-5de3-8fa8-d2522dec364c
DOI: 10.1101/2025.01.29.635561

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Infection and herbicide exposure implicate c-Abl kinase in α-Synuclein Ser129 phosphorylationDOI 10.1101/2025.01.29.635561Read

The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson’s diseaseSemantic proximity Read

STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein OligomersSemantic proximity Read

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Semantic proximity Read

Helicobacter pylori-Vacuolating Cytotoxin A Induces Neurotoxic Neuroinflammation in Human Multicellular ModelsSemantic proximity Read

c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic PotentialSemantic proximity Read

Sex specific effects of environmental toxin-derived alpha synuclein on enteric neuronal-epithelial interactionsSemantic proximity Read

<i>Helicobacter pylori</i> infection and α-synuclein pathology drive parallel neurodegenerative pathways in the substantia nigraSemantic proximity Read

USP14 regulates pS129 α-synuclein levels and oxidative stress in human SH-SY5Y dopaminergic cellsSemantic proximity Read

Ser129 Phosphorylation Paradox: Non-phosphorylated α-Synuclein Drives Parkinson’s Disease-like Pathogenesis <i>in Vivo</i>Semantic proximity Read

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.Semantic proximity Read

Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.Semantic proximity Read

A <i>de novo</i> compound targeting α-synuclein improves deficits in models of Parkinson's diseaseSemantic proximity Read