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Article

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.

Acta neuropathologica communications - 15 Jun 2017

Arawaka Shigeki, Sato Hiroyasu, Sasaki Asuka, Koyama Shingo, Kato Takeo

Abstract excerpt

Parkinson's disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD. In contrast, only 4% of total α-synuclein is phosphorylated at Ser129 in brains with normal individuals. It is unclear why extensive phosphorylation occurs in the pathological...

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Identifiers

PMID: 28619113
DOI: 10.1186/s40478-017-0452-6
PMCID: PMC5472914

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