Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic Potential

11 Sept 2017

Abstract excerpt

Although the etiology of Parkinson's disease (PD) is poorly understood, oxidative stress has long been implicated in the pathogenesis of the disease. However, multifaceted and divergent signaling cascades downstream of oxidative stress have posed challenges for researchers to identify a central component of the oxidative stress-induced pathways causing neurodegeneration in PD. Since 2010, c-Abl-a non-receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Myeloid Leukemia Treatments
Share to Fungal Plant Pathogen Control
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29103051
DOI: 10.3233/jpd-171191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Abl and Parkinson’s Disease: Mechanisms and Therapeutic PotentialPMID 29103051Read ↗

c-Abl in Neurodegenerative DiseaseSemantic proximity Read ↗

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function.Semantic proximity Read ↗

Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative StressSemantic proximity Read ↗

The Role of c-Abl Tyrosine Kinase in Brain and Its PathologiesSemantic proximity Read ↗

The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson’s diseaseSemantic proximity Read ↗

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s DiseaseSemantic proximity Read ↗

Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovationsSemantic proximity Read ↗

Roles for c-Abl in postoperative neurodegenerationSemantic proximity Read ↗

Ceramides in Parkinson’s Disease: From Recent Evidence to New HypothesesSemantic proximity Read ↗

Parkin as a Molecular Bridge Linking Alzheimer’s and Parkinson’s Diseases?Semantic proximity Read ↗

Activation mechanisms of the E3 ubiquitin ligase parkin.Semantic proximity Read ↗

LRRK2 mutations: at the crossroads of dopamine, iron, and calcium imbalance in Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.