Article

STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein Oligomers

2025-03-26

Abstract excerpt

The accumulation of alpha-synuclein (a-Syn) as toxic oligomers, and subsequently in Lewy bodies, is a pathological hallmark of Parkinson’s disease (PD) and other synucleinopathies. Molecular chaperones and co-chaperones are expected to act in concert to maintain physiological activities of proteins, including a-Syn, but in neurodegeneration this process can become mal-adaptive. Transcript levels of Stress inducibl...

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Literature Corpus work: 565a187a-a5f5-5dbe-956b-f3106c7978be
DOI: 10.1101/2025.03.26.645247

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