Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.

The Journal of biological chemistry - 22 Aug 2008

Sugeno Naoto, Takeda Atsushi, Hasegawa Takafumi, Kobayashi Michiko, Kikuchi Akio, Mori Fumiaki, Wakabayashi Koichi, Itoyama Yasuto

Abstract excerpt

alpha-Synuclein is a major protein component deposited in Lewy bodies and Lewy neurites that is extensively phosphorylated at Ser(129), although its role in neuronal degeneration is still elusive. In this study, several apoptotic pathways were examined in alpha-synuclein-overexpressing SH-SY5Y cells. Following the treatment with rotenone, a mitochondrial complex I inhibitor, wild type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Caspase 3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Death

Share to Golgi Apparatus

Share to Lewy Bodies

Share to Protein Denaturation

Share to Rotenone

Share to Serine

Source

Identifiers

PMID: 18562315
DOI: 10.1074/jbc.M802223200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.PMID 18562315Read ↗

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates.Semantic proximity Read ↗

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.Semantic proximity Read ↗

[Cellular pathophysiology of Parkinson's disease].Semantic proximity Read ↗

Combination of alpha-synuclein aggregation inhibitor anle138b and ER stress inhibitor AMG PERK 44 increases neuroprotection in Parkinson’s disease organoid modelSemantic proximity Read ↗

Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis.Semantic proximity Read ↗

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.Semantic proximity Read ↗

Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.Semantic proximity Read ↗

α-synuclein phosphorylation and truncation are normal events in the adult human brain.Semantic proximity Read ↗

HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells.Semantic proximity Read ↗

Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body DiseaseSemantic proximity Read ↗

Characterization and regulation of alpha-synuclein phosphorylation in enteric neurons under physiological conditionsSemantic proximity Read ↗

Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.