Article

ELX: An Empirical Two-Stage Combinatorial Approach to Identify Pleiotropic Genetic Effects by using Genome-Wide Association Summary Statistics

2022-05-19

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified genetic determinants underlying complex human diseases. Pleiotropic effects occur when a single genetic variant influences multiple phenotypes or illnesses, widely observed in recent GWAS findings. However, no systematic effort has been made to statistically detect pleiotropic effects across many traits/phenotypes due to the lack of easy-to-use st...

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Literature Corpus work: 9ddb4e72-0718-5be1-ab49-3b361208e08d
DOI: 10.21203/rs.3.rs-1578442/v1

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