A robust pleiotropy method with applications to lipid traits and to inflammatory bowel disease subtypes with sample overlap

Abstract excerpt

Pleiotropy, the phenomenon where a genetic region confers risk to multiple traits, is widely observed, even among seemingly unrelated traits. Knowledge of pleiotropy can improve understanding of biological mechanisms of diseases/traits, and can potentially guide identification of molecular targets or help predict side effects in drug development. However, statistical approaches for identifying pleiotropy...