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Article

Identifying pleiotropic genes via the composite test amidst the complexity of polygenic traits.

Briefings in bioinformatics - 23 May 2024

Lai En-Yu, Huang Yen-Tsung

Abstract excerpt

Identifying the causal relationship between genotype and phenotype is essential to expanding our understanding of the gene regulatory network spanning the molecular level to perceptible traits. A pleiotropic gene can act as a central hub in the network, influencing multiple outcomes. Identifying such a gene involves testing under a composite null hypothesis where the gene is associated with, at most, one trait....

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Identifiers

PMID: 39007593
DOI: 10.1093/bib/bbae327
PMCID: PMC11247409

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