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Article

PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics.

American journal of human genetics - 7 Jan 2021

Lee Cue Hyunkyu, Shi Huwenbo, Pasaniuc Bogdan, Eskin Eleazar, Han Buhm

Abstract excerpt

Identifying and interpreting pleiotropic loci is essential to understanding the shared etiology among diseases and complex traits. A common approach to mapping pleiotropic loci is to meta-analyze GWAS summary statistics across multiple traits. However, this strategy does not account for the complex genetic architectures of traits, such as genetic correlations and heritabilities. Furthermore, the interpretation is...

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Identifiers

PMID: 33352115
DOI: 10.1016/j.ajhg.2020.11.017
PMCID: PMC7820744

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