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Article

LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies.

BMC genomics - 28 Jun 2018

Yang Yi, Dai Mingwei, Huang Jian, Lin Xinyi, Yang Can, Chen Min, Liu Jin

Abstract excerpt

BACKGROUND: To date, genome-wide association studies (GWAS) have successfully identified tens of thousands of genetic variants among a variety of traits/diseases, shedding light on the genetic architecture of complex disease. The polygenicity of complex diseases is a widely accepted phenomenon through which a vast number of risk variants, each with a modest individual effect, collectively contribute to the...

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PMID: 29954342
DOI: 10.1186/s12864-018-4851-2
PMCID: PMC6022345

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