Article
Testing Genetic Pleiotropy with GWAS Summary Statistics for Marginal and Conditional Analyses.
Genetics - 1 Dec 2017
Deng Yangqing, Pan Wei
Abstract excerpt
There is growing interest in testing genetic pleiotropy, which is when a single genetic variant influences multiple traits. Several methods have been proposed; however, these methods have some limitations. First, all the proposed methods are based on the use of individual-level genotype and phenotype data; in contrast, for logistical, and other, reasons, summary statistics of univariate SNP-trait associations are...
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