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Article

Benchmarking of univariate pleiotropy detection methods applied to epilepsy.

Human mutation - 1 Sept 2022

Adesoji Oluyomi M, Schulz Herbert, May Patrick, Krause Roland, Lerche Holger, Nothnagel Michael

Abstract excerpt

Pleiotropy is a widespread phenomenon that may increase insight into the etiology of biological and disease traits. Since genome-wide association studies frequently provide information on a single trait only, only univariate pleiotropy detection methods are applicable, with yet unknown comparative performance. Here, we compared five such methods with respect to their ability to detect pleiotropy, including...

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PMID: 35620985
DOI: 10.1002/humu.24417

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