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Article

Summary statistics-based association test for identifying the pleiotropic effects with set of genetic variants.

Bioinformatics (Oxford, England) - 3 Apr 2023

Bu Deliang, Wang Xiao, Li Qizhai

Abstract excerpt

MOTIVATION: Traditional genome-wide association study focuses on testing one-to-one relationship between genetic variants and complex human diseases or traits. While its success in the past decade, this one-to-one paradigm lacks efficiency because it does not utilize the information of intrinsic genetic structure and pleiotropic effects. Due to privacy reasons, only summary statistics of current genome-wide...

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PMID: 37027223
DOI: 10.1093/bioinformatics/btad182
PMCID: PMC10115469

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