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Article

Divided-and-combined association test for pleiotropic effects with GWAS summary statistics.

BMC genomics - 30 Apr 2026

Hu Boheng, Chen Yaoyao, Zheng Xueqin, Guo Hongping

Abstract excerpt

Many genome-wide association studies (GWAS) conducted over the past two decades have focused on testing the one-to-one association between genetic variants and complex diseases or phenotypes. Despite their considerable success, such one-to-one testing approaches are underpowered because they do not utilize information on pleiotropic effects. Currently available public GWAS summary statistics provide resources for...

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PMID: 42062874
DOI: 10.1186/s12864-026-12883-9
PMCID: PMC13277180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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