Article
Reprogramming of Cellular Plasticity via ETS and MYC Core-Regulatory Circuits during Response to MAPK Inhibition in BRAF-Mutant Colorectal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Aug 2026
Lee Hey Min, Zheng Zhao, Sorokin Alexey, Wong Chi Wut, Napolitano Stefania, Chowdhury Saikat, Kanikarla Marie Preeti, Singh Anand K, Kochat Veena, Bristow Christopher A, Srinivasan Sanjana, Peoples Michael, Arslan Emre, Alshenaifi Jumanah Yousef, Villarreal Oscar E, Morris Van K, Shen John Paul, Meric-Bernstam Funda, Jain Abhinav K, Fowlkes Natalie Wall, Anderson Amanda, Menter David G, Saw Ajay Kumar, Rai Kunal, Kopetz Scott
Abstract excerpt
PURPOSE: Aberrant enhancer dynamics play a critical role in the initiation and progression of colorectal cancer, particularly in the BRAFV600E-mutated metastatic subtype, which uniquely exhibits a strong epigenetic phenotype. Building on this epigenetic vulnerability, bromodomain 2, a reader of H3K27ac-marked enhancers, was found to be synthetically lethal with BRAF + EGFR inhibition. EXPERIMENTAL DESIGN: We...
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