Article

A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer

2022-04-10

Abstract excerpt

<h4>ABSTRACT</h4> The human genome contains regulatory elements, such as enhancers, that are often rewired by cancer cells for the activation of genes that promote tumorigenesis and resistance to therapy. This is especially true for cancers that have little or no known driver mutations within protein coding genes, such as ovarian cancer. Herein, we have utilized an integrated set of genomic and epigenomic dataset...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a6c25fd-5de1-5dc2-9a68-2c0014f486b7
DOI: 10.1101/2022.04.08.487699

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancerDOI 10.1101/2022.04.08.487699Read

Super-enhancers in the control of cell identity and disease.Semantic proximity Read

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.Semantic proximity Read

Spatial and clonality-resolved 3D cancer genome alterations reveal enhancer-hijacking as a potential prognostic marker for colorectal cancerSemantic proximity Read

Super-enhancers are transcriptionally more active and cell-type-specific than stretch enhancersSemantic proximity Read

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networksSemantic proximity Read

Genome-wide profiling of active enhancers in colorectal cancerSemantic proximity Read

Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networksSemantic proximity Read

A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer.Semantic proximity Read

Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations.Semantic proximity Read

A new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loopsSemantic proximity Read

Integrative analysis reveals genomic and epigenomic signatures of super-enhancers and its constituentsSemantic proximity Read

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient SamplesSemantic proximity Read