Article
Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes.
eLife - 13 Feb 2019
Hung Stevephen, Saiakhova Alina, Faber Zachary J, Bartels Cynthia F, Neu Devin, Bayles Ian, Ojo Evelyn, Hong Ellen S, Pontius W Dean, Morton Andrew R, Liu Ruifu, Kalady Matthew F, Wald David N, Markowitz Sanford, Scacheri Peter C
Abstract excerpt
Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to pinpoint potential enhancer-activating mutations in colorectal cancer (CRC). Analysis of a genetically-diverse cohort of CRC specimens revealed that microsatellite...
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