Article

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models

2022-07-24

Abstract excerpt

Patient-Derived Organoids (PDO) and Xenografts (PDX) are the current gold standards for patient derived models of cancer (PDMC). Nevertheless, how patient tumor cells evolve in these models and the impact on drug response remains unclear. Herein, we compared the transcriptomic and chromatin accessibility landscapes of six matched sets of colorectal cancer (CRC) PDO, PDX, PDO-derived PDX (PDOX), and original patien...

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Literature Corpus work: 24c14268-48d2-5366-9554-35839809eb5f
DOI: 10.1101/2022.07.24.501300

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