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Cyclic mechanical stretching stimuli promotes angiocrine signals during <i>in vitro</i> liver bud formation from human pluripotent stem cells

2023-06-11

Abstract excerpt

Liver organoids derived from human pluripotent stem cells (hPSCs) allow elucidation of liver development and have great potential for drug discovery. However, current methods for generating liver organoids using biochemical substances do not realize the vascular network of the liver lobule, due to the lack of knowledge of the role of in vivo mechanical environments during liver development. Here, we investigate t...

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Literature Corpus work
9d92ad13-ffc8-5488-9476-c402664e4c8b
DOI
10.1101/2023.06.11.544492
Open publication

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Cyclic mechanical stretching stimuli promotes angiocrine signals during <i>in vitro</i> liver bud formation from human pluripotent stem cellsDOI 10.1101/2023.06.11.544492
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